The efficacy and safety of the Timothy grass allergy sublingual immunotherapy tablet in Canadian adults and children
نویسندگان
چکیده
منابع مشابه
The efficacy and safety of the Timothy grass allergy sublingual immunotherapy tablet in Canadian adults and children
BACKGROUND The effect of sublingual Timothy grass immunotherapy tablet 2800 BAU (grass SLIT-T) has been evaluated in three North American trials in adults and children who have allergic rhinitis with or without conjunctivitis (AR/C). This paper examines the effects of grass SLIT-T in Canadians. METHODS Data for grass-allergic Canadians in three randomized, placebo-controlled, double-blind tri...
متن کاملEfficacy and safety of MK-7243: a grass allergy sublingual immunotherapy tablet evaluated in Canadian adults and children
Background The effect of MK-7243 (2800 BAU/75,000 SQ [~15 μg of Phleum pratense p 5], Merck/ALK-Abelló), a sublingual Timothy grass immunotherapy tablet, has been evaluated in several randomized, placebo-controlled, double-blind trials; three of these trials were conducted in adults and children in North America (the United States and Canada) who have allergic rhinitis with or without conjuncti...
متن کاملEfficacy and Safety of Timothy Grass Allergy Immunotherapy Tablets in North American Children and Adolescents
CONCLUSIONS. Although all SLIT regimens resulted in an improvement in clinical efficacy, prolonged SLIT was the most effective. The reduction in IL-4 and increase in IL-10 production is consistent with observations from subcutaneous immunotherapy studies and provides insight into the mechanism of SLIT. These cytokine changes might serve as an objective marker of efficacy of SLIT for patients on...
متن کاملEfficacy and Safety of Timothy Grass Allergy Immunotherapy Tablets in North American Children and Adolescents
CONCLUSIONS. Although all SLIT regimens resulted in an improvement in clinical efficacy, prolonged SLIT was the most effective. The reduction in IL-4 and increase in IL-10 production is consistent with observations from subcutaneous immunotherapy studies and provides insight into the mechanism of SLIT. These cytokine changes might serve as an objective marker of efficacy of SLIT for patients on...
متن کاملEfficacy of Timothy grass allergy immunotherapy tablet (AIT) treatment in Canadian children and adults with grass pollen-induced allergic rhinoconjunctivitis (ARC)
Methods Subjects 5 years and older with ARC with/without asthma received once-daily 2800 BAU sublingual grass AIT (oral lyophilisate, Phleum pratense, 75,000 SQ-T, ~15μg Phl p5) or placebo starting approximately 16 weeks before and continuing throughout the 2009 grass pollen season (GPS). Subjects used daily e-diaries to record ARC symptoms and use of symptomatic medications from randomization ...
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ژورنال
عنوان ژورنال: Allergy, Asthma & Clinical Immunology
سال: 2014
ISSN: 1710-1492
DOI: 10.1186/1710-1492-10-53